Alpha-ketoglutarate is a natural compound that works in many pathways in the body, including making muscle and healing wounds. It's also used as medicine. Alpha-ketoglutarate seems to help the body rebuild muscle and reduce muscle loss after surgery or trauma. It might also have anti-aging effects.
What is the function of alpha Ketoglutaric acid?
Alpha-Ketoglutarate (AKG) is a biological substance thatplays important roles in cell metabolism and physiology. AKG is synthesized from glucose or oxaloacetate plus pyruvate. As an intermediate of the tricarboxylic acid cycle, AKG is essential for the oxidation of fatty acids, amino acids, and glucose.
What does AKG do to the body?
AKGhelps maintain nitrogen balance within the body, is a precursor to several amino acids, is a source of energy for cells, and functions as an antioxidant. It is used to produce glutamine.
Is AKG anti-aging?
Dietary alpha-ketoglutarate (AKG)declines agingand prolongs lifespan in model organisms. AKG promotes longevity acting more likely as a hormetin than as a mimetic of dietary restriction.
What are the side effects of alpha ketoglutaric acid?
No significant side effects caused by alpha-ketoglutarate have been reported in humansbut as with any supplement, if you do experience any adverse effects you should cease taking it immediately and consult your doctor.
What is ketoglutaric acid benefits?
Alpha-ketoglutarate is a natural compound that works in many pathways in the body, including making muscle and healing wounds. It's also used as medicine. Alpha-ketoglutarate seems tohelp the body rebuild muscle and reduce muscle loss after surgery or trauma. It might also have anti-aging effects.
Is AKG good for kidneys?
Alpha-ketoglutarate isused for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.
What is deficiency of alpha-ketoglutarate?
The alpha-ketoglutarate dehydrogenase complex (KGDHC) deficiency isa rare autosomal recessive disorder, most often presenting with severe encephalopathy and hyperlactatemia with neonatal onset. KGDHC is mitochondrial enzyme complex, and functions in the TCA cycle.
AKG also plays a role in maintaining stem cell health (R), and in bone and gut metabolism (R). Calcium alpha-ketoglutarate is also involved in collagen production, can reduce fibrosis, andcan thus play a role in maintaining healthy, youthful skin and delaying aging(R,R).
What are natural sources of AKG?
Sourcing Ca-AKG from Food
Meat: Pork and beef are red meat with calcium alpha-ketoglutarate. ...
Fish: Salmon and trout are two fish species that also contain calcium alpha-ketoglutarate. ...
Dairy Products: Milk, cheese, and yogurt are dairy products that contain calcium alpha-ketoglutarate.
When should I take the AKG supplement?
For our Ca-AKG supplement, we recommend taking one capsulein the morning after breakfast or lunch. Please always consult with a healthcare provider before starting any new supplement.
Where does alpha-ketoglutaric acid come from?
Oxidative decarboxylation of isocitrate in the TCA cycle and oxidative desamination of glutamate are main sources of AKG in the cell. As a TCA cycle intermediate, AKG is involved in ATP production via mitochondrial oxidative phosphorylation.
Ingredients:
1 vegetarian capsule contains: % NRV*
Alpha-ketoglutaric acid
300 mg sodium
* Percentage of nutrient reference values according to Regulation (EU) No 1169/2011. (NRV = Nutrient Reference Value)