{"product_id":"nifedipine-treat-heart-diseases-high-blood-pressure","title":"NIFEDIPINE, treat heart diseases, high blood pressure","description":"\u003ch1 class=\"\" data-mce-fragment=\"1\"\u003e\u003cspan class=\"product__headline text-larger\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eNIFEDIPINE LM 20 Dilution 10 ml\u003c\/span\u003e\u003c\/span\u003e\u003c\/h1\u003e\n\u003ch3\u003e\u003cspan\u003eNIFEDIPINE, treat heart diseases, high blood pressure indication\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe drug is used to treat heart diseases associated with insufficient oxygen supply to the heart muscle and to treat high blood pressure.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eThe drug is used in\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eSymptoms (e.g. pain or tightness in the chest area) in conditions with insufficient oxygen supply to the heart muscle (angina pectoris):\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eunder stress: chronically stable angina pectoris (stress angina)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003edue to vasospasm: vasospastic angina pectoris (Prinzmetal's angina, variant angina)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003enon-organic hypertension\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehypertensive crisis\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eNotice:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIn patients with non-organ related hypertension or chronic angina pectoris treated with nifedipine immediate-release formulations (this preparation is one of them), there is evidence of a dose-dependent increase in cardiovascular complications (e.g. myocardial infarction) and an increase resulting in mortality.\u003cspan\u003e \u003c\/span\u003eTherefore, the drug should only be used in these two diseases if other drugs are not indicated.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eNIFEDIPINE, treat heart diseases, high blood pressure dosage\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eAlways take this medicine exactly as your doctor or pharmacist has told you.\u003cspan\u003e \u003c\/span\u003eCheck with your doctor or pharmacist if you are not sure.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTreatment should be individualized as much as possible, depending on the severity of the disease and the patient's response.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDepending on the clinical picture in question, the recommended dose should be gradually reached.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePatients with severe problems with blood flow to the brain (cerebrovascular disease) should be treated with a lower dose.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAn adjustment of the nifedipine dose may be necessary if other medicinal products that inhibit or enhance a certain enzyme system (cytochrome P450 3A4) are used concomitantly.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003edosage\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eUnless otherwise prescribed by the doctor, the usual dose for adults is:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eCoronary heart disease\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003ehigh blood pressure\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e10 - 20 drops 3 times a day (equivalent to 30 - 60 mg nifedipine per day).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe maximum daily dose is 60 mg nifedipine.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003ehypertensive crisis\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIf necessary, 10 drops (equivalent to 10 mg nifedipine).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf there is no or insufficient effect, another dose of 10 mg nifedipine can be given after about 30 minutes at the earliest.\u003cspan\u003e \u003c\/span\u003eWith shorter intake intervals and\/or higher doses, dangerous reductions in blood pressure can occur.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eUse in specific patient groups\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003echildren and young people\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe medicine is not recommended for use in children and adolescents under 18 years of age as there is limited data on safety and efficacy in this age group.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eElderly patients\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eFor maintenance therapy, elderly patients may require a lower dose than younger patients.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003ePatients with impaired liver function\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ePatients with hepatic impairment should be carefully monitored and a dose reduction may be necessary.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003ePatients with impaired renal function\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eDose adjustment is not required in these patients.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eduration of use\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe doctor treating you determines the duration of the intake.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePlease talk to your doctor or pharmacist if you have the impression that the effect is too strong or too weak.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you take more than you should\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eAn overdose of the drug can lead to a severe drop in blood pressure, slower or faster heart rate, clouding of consciousness to the point of complete unconsciousness, increased blood sugar levels (hyperglycaemia), reduced blood flow to important organs and shock caused by heart failure with accumulation of fluid in the lungs (pulmonary oedema).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf you suspect an overdose, contact a doctor\/emergency doctor immediately so that he can decide how to proceed.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you forget to take a dose\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eDo not take a double dose to make up for a forgotten dose.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you stop taking it\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ePlease do not interrupt or stop treatment with the medicine without first discussing this with your doctor.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDiscontinuation of treatment with the preparation - especially at high doses - should be done gradually.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIf you have any further questions on the use of this medicine, ask your doctor or pharmacist.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eNIFEDIPINE, treat heart diseases, high blood pressure way\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eTo take\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe drops are taken after meals with sufficient liquid (e.g. 1 glass of water), preferably in the morning, at noon and in the evening, if possible at the same time.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe medicine must not be taken with grapefruit juice.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf you are taking single doses of more than 20 mg nifedipine, you should leave a gap of at least 2 hours between single doses.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDue to the photosensitivity of the active ingredient nifedipine, the solution must be taken immediately after removing it from the bottle.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eside NIFEDIPINE, treat heart diseases, high blood pressure effects\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eLike all medicines, this medicine can cause side effects, although not everybody gets them.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eThe frequency of side effects is based on the following categories:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003every common: more than 1 in 10 people treated\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecommon: affects 1 to 10 users in 100\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003euncommon: affects 1 to 10 users in 1,000\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRare: affects 1 to 10 users in 10,000\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003every rare: affects less than 1 in 10,000 people\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003enot known: frequency cannot be estimated from the available data\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003epossible side effects\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eDiseases of the blood and lymphatic system\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eRare: Changes in the blood picture such as a reduction in the number of red or white blood cells or blood platelets (anaemia, leukopenia, thrombocytopenia), bleeding from the skin and mucous membranes with a reduced number of blood platelets (thrombocytopenic purpura).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVery rare: Severe reduction in the number of certain white blood cells (agranulocytosis).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003ediseases of the immune system\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: Allergic reactions, allergic tissue swelling, swelling of the face and mucous membranes in the mouth and throat (angioedema) including laryngeal swelling, which can be life-threatening.\u003cspan\u003e \u003c\/span\u003eitching, rash.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRare: hives.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFrequency not known: Acute general allergic reactions that may be life-threatening under certain circumstances (anaphylactic\/anaphylactoid reactions).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003ePsychiatric Illnesses\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: anxiety reactions, sleep disorders.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eMetabolic and nutritional disorders\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eRare: increase in blood sugar levels.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDiseases of the nervous system\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eVery common: headache.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCommon: dizziness, lightheadedness, weakness.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: migraine, muscle tremors, abnormal sensations (e.g. tingling, furry feeling), sometimes painful.\u003cspan\u003e \u003c\/span\u003eDrowsiness\/fatigue, nervousness.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFrequency not known: Decreased sensitivity to touch stimuli.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eeye diseases\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: visual disturbances.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFrequency not known: eye pain.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eheart diseases\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCommon: palpitations.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: increased heart rate, chest pain (angina pectoris).\u003cspan\u003e \u003c\/span\u003eOccasionally, attacks of angina pectoris may occur, particularly at the beginning of treatment, or in patients with existing angina pectoris, the frequency, duration and severity of attacks may increase.\u003cspan\u003e \u003c\/span\u003eThe occurrence of a heart attack has been described in isolated cases.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVery rare: myocardial infarction.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003evascular diseases\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eVery common: Tissue swelling due to fluid retention.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCommon: dilatation of blood vessels (e.g. flushing of the face).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: drop in blood pressure, fainting for a short time.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eRespiratory, thoracic and mediastinal disorders\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: Nosebleeds, nasal congestion, shortness of breath.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDigestive tract diseases\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCommon: constipation, nausea.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: gastrointestinal pain, abdominal pain, indigestion, flatulence, dry mouth.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRare: overgrowth of gums, loss of appetite, feeling of fullness, belching.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFrequency not known: vomiting, esophagitis.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eLiver and biliary diseases\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: Transient increase in liver enzymes.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRare: jaundice.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eSkin and subcutaneous tissue disorders\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCommon: painful swelling and redness of the arms and legs (erythromelalgia), especially at the beginning of treatment.\u003cspan\u003e \u003c\/span\u003eSweat.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: reddening of the skin with a feeling of warmth.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRare: Allergic photosensitivity of the skin.\u003cspan\u003e \u003c\/span\u003ePalpable, small-spotted hemorrhages in the skin and mucous membrane.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVery rare: scaly skin inflammation (exfoliative dermatitis).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFrequency not known: Serious and life-threatening skin changes with detachment and blistering of the epidermis (scalded skin syndrome, toxic epidermal necrolysis).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eMusculoskeletal, connective tissue and bone disorders\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: muscle cramps, swollen joints, muscle pain.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFrequency not known: joint pain.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDiseases of the kidneys and urinary tract\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: Increased urge to urinate and increased daily urine output.\u003cspan\u003e \u003c\/span\u003ePainful urge to urinate with difficulty in urinating.\u003cspan\u003e \u003c\/span\u003eIn the case of renal insufficiency, a temporary deterioration in renal function is possible.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDiseases of the genital organs and the mammary gland\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: erectile dysfunction.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRare: Enlargement of the male breasts (gynaecomastia) that disappear after stopping the drug.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eGeneral disorders and administration site conditions\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCommon: General malaise.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eUncommon: Non-specific pain, chills.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eA significant drop in blood pressure can occur in dialysis patients with high blood pressure and reduced blood volume.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf you get any side effects, talk to your doctor or pharmacist.\u003cspan\u003e \u003c\/span\u003eThis also applies to side effects that are not specified.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eNIFEDIPINE, treat heart diseases, high blood pressure interactions\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eWhen taking the preparation with other medicines\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eTell your doctor or pharmacist if you are taking\/using, have recently taken\/used or might take\/use any other medicines.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eWhat other medicines affect the way this medicine works?\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eNifedipine (the active ingredient in this medicine) is broken down with the participation of a specific enzyme system (cytochrome P450 3A4).\u003cspan\u003e \u003c\/span\u003eTherefore, the concomitant use of drugs that affect this enzyme system can, in principle, lead to interactions of these drugs with the preparation.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eBoth the extent and duration of interactions should be considered if the drug is to be taken with the drugs listed below.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eWeakening of the effect of other medicines:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ePhenytoin (active substance used to treat cardiac arrhythmias and epilepsy): Reduces the effectiveness of nifedipine.\u003cspan\u003e \u003c\/span\u003eIf both drugs are taken at the same time, the reaction to nifedipine (the active ingredient in this drug) should be observed and an increase in the dose of this drug should be considered if necessary.\u003cspan\u003e \u003c\/span\u003eAfter stopping the use of phenytoin, the dose of nifedipine may need to be adjusted again.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCarbamazepine and phenobarbital (active substances used to treat epilepsy): Taking this medicine at the same time can lead to a weakened effect of the preparation.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRifampicin (anti-tuberculosis medicine): Causes the body to break down nifedipine (the active ingredient in this medicine) more quickly.\u003cspan\u003e \u003c\/span\u003eRifampicin must not be used concomitantly with treatment with nifedipine, since effective blood levels of nifedipine are not achieved.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eEnhancement of the nifedipine effects and side effects by other drugs:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you are using the following other medicines concomitantly with this product, blood pressure should be monitored and a reduction in the dose of Nifedipine ratiopharm 20 mg\/ml considered, if necessary:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCertain antibiotics (e.g. erythromycin)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003efluoxetine and nefazodone (anti-sad mood remedies, antidepressants)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRitonavir (anti-HIV medicine)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCertain antifungal medicines (e.g. ketoconazole)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eQuinupristin \/ Dalfopristin (antibiotics)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecimetidine (medicine against stomach and intestinal ulcers)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003evalproic acid (anti-epilepsy medicine)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003etricyclic antidepressants (medicines for depression)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003evasodilators (medicines that dilate blood vessels)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecisapride (drug that speeds up bowel movement)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eHow does this preparation affect the effects of other medicines?\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eAntihypertensive drugs:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eThe blood pressure-lowering effect of other medicines of different active substance groups can be increased by this preparation, e.g.\u003cspan\u003e \u003c\/span\u003eB. from:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eDiuretics (water pills)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ebeta-receptor blockers (medicines for high blood pressure)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eACE inhibitors (medicines for high blood pressure)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eangiotensin receptor antagonists (medicines for high blood pressure)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eother calcium antagonists (medicines for high blood pressure)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ealpha-receptor blockers (medicines for high blood pressure and heart failure)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePDE 5 inhibitors (medicines to treat erectile dysfunction)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAlpha-methyldopa (medicine for high blood pressure)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIn the case of simultaneous treatment with beta-receptor blockers (active substance group of antihypertensive drugs), signs of heart failure may occasionally occur.\u003cspan\u003e \u003c\/span\u003eYour doctor will carefully monitor the course of treatment in these cases.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDigoxin (active ingredient to strengthen the heart), theophylline (active ingredient to widen the bronchi): The concentration of these medicines in the blood may increase.\u003cspan\u003e \u003c\/span\u003eSigns of digoxin overdose should be observed and, if necessary, the digoxin dose reduced by the doctor (after determining the digoxin concentration in the blood).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVincristine (active ingredient for the treatment of tumours): The excretion of vincristine is reduced, which can increase the side effects of vincristine.\u003cspan\u003e \u003c\/span\u003eYour doctor may prescribe a reduction in the dose of vincristine.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCephalosporins (drugs used to treat infections): levels of cephalosporins in the blood may be increased.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eQuinidine (active substance for the treatment of cardiac arrhythmias): In individual cases, the preparation causes a drop in the quinidine content in the blood or the discontinuation of nifedipine causes a significant increase (control of the quinidine content in the blood!).\u003cspan\u003e \u003c\/span\u003eIn other cases, quinidine has also been reported to increase blood levels of nifedipine.\u003cspan\u003e \u003c\/span\u003eIt is therefore recommended that blood pressure is carefully monitored when both drugs are used concomitantly.\u003cspan\u003e \u003c\/span\u003eIf necessary, the dose of this medicine should be reduced.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTacrolimus (active ingredient to prevent transplant rejection after e.g. liver and kidney transplants): If nifedipine is taken at the same time, increased tacrolimus blood levels may occur, so that the tacrolimus dose should be reduced in individual cases.\u003cspan\u003e \u003c\/span\u003eRegular monitoring of tacrolimus blood levels is recommended.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMagnesium sulfate (intravenous): When co-administered with nifedipine, an excessive fall in blood pressure may occur.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eTake with food, drink and alcohol\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eGrapefruit juice can increase the blood pressure lowering effect of this medicine.\u003cspan\u003e \u003c\/span\u003eThis effect lasts for at least 3 days after the last ingestion of grapefruit juice.\u003cspan\u003e \u003c\/span\u003eConsuming grapefruit or grapefruit juice should therefore be avoided in connection with the nifedipine treatment.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eNIFEDIPINE, treat heart diseases, high blood pressure Contraindications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eThe drug must not be taken\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eif you are allergic to nifedipine or any of the other ingredients of this medicine\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you have been in shock\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you suffer from narrowing of the heart valves (aortic stenosis).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you have symptoms (e.g. pain or tightness in the chest) at rest in conditions with insufficient oxygen supply to the heart muscle (angina pectoris).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you have had an acute heart attack within the last 4 weeks\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you are taking medicines containing the active substance rifampicin (medicines for tuberculosis) at the same time\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003epregnancy NIFEDIPINE, treat heart diseases, high blood pressure and breast feeding period\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIf you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eA harmful drug effect on the unborn child and the infant cannot be ruled out.\u003cspan\u003e \u003c\/span\u003eTherefore, you should not use the drug during pregnancy.\u003cspan\u003e \u003c\/span\u003eAny use during pregnancy should only be done after a very careful individual benefit-risk assessment and should only be considered if all other treatment options are unsuitable or have proven to be ineffective.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf treatment with the drug is necessary during breast-feeding, it is recommended to wait 3-4 hours after taking the drug, as nifedipine (the active ingredient in this drug) passes into breast milk and there is no experience of possible effects on the infant.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIn individual cases, the drug can impair sperm function.\u003cspan\u003e \u003c\/span\u003eIf repeated artificial insemination is unsuccessful, nifedipine should be considered as a possible cause.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003epatient NIFEDIPINE, treat heart diseases, high blood pressure notes\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eWarnings and Precautions\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ePlease talk to your doctor or pharmacist before taking this medicine.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eTreatment with the preparation requires regular medical supervision\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eif you have low blood pressure (systolic below 90 mmHg).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you suffer from insufficiently treated heart muscle weakness (decompensated heart failure).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you are a dialysis patient with severe high blood pressure and reduced circulating blood volume, as a significant drop in blood pressure may occur\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you are pregnant or breastfeeding\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTaking the drug can cause an excessive drop in blood pressure with an accelerated heartbeat (reflex tachycardia), which can lead to cardiovascular problems.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAttacks of angina pectoris may occasionally occur, particularly at the beginning of treatment, or an increase in the frequency, duration and severity of attacks in patients with existing angina pectoris.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eHeart attacks have been reported very rarely.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe active substance in this medicine, nifedipine, is broken down with the participation of a specific enzyme system (cytochrome P450 3A4).\u003cspan\u003e \u003c\/span\u003eThis enzyme system can be inhibited or increased by other medicines.\u003cspan\u003e \u003c\/span\u003eThis can change the effects and side effects of the drug\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you take the medicine at the same time as other medicines that inhibit this enzyme system, this can result in increased effects, but also increased side effects of the medicine.\u003cspan\u003e \u003c\/span\u003eThese include e.g.\u003cspan\u003e \u003c\/span\u003eB. the following medicines:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ecertain antibiotics (e.g. erythromycin)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecertain anti-HIV medicines (e.g. ritonavir)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecertain antifungal medicines (e.g. ketoconazole)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNefazodone and fluoxetine (anti-sad mood remedies, antidepressants)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eQuinupristin \/ Dalfopristin (antibiotics)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003evalproic acid (anti-epilepsy medicine)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecimetidine (medicine against stomach and intestinal ulcers)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf the drug is used concomitantly with any of these drugs, blood pressure should be monitored and a reduction in the nifedipine dose considered, if necessary.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFor use in special patient groups, see category \"Dosage\".\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eAbility to drive and use machines\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eTreatment with this drug requires regular medical supervision.\u003cspan\u003e \u003c\/span\u003eDue to the different reactions that occur individually, the ability to react can be changed to such an extent that the ability to actively participate in road traffic, to operate machines or to work without a secure footing is impaired.\u003cspan\u003e \u003c\/span\u003eThis applies to a greater extent at the start of treatment, when the dose is increased and when the drug is changed, as well as in combination with alcohol.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ARCANA Dr. Sewerin GmbH \u0026 Co. KG","offers":[{"title":"Default Title","offer_id":42898434293945,"sku":"12969628","price":92.47,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0637\/3952\/7353\/files\/nifedipine-treat-heart-diseases-high-blood-pressure-uk.jpg?v=1716203669","url":"https:\/\/eliveragroup.co.uk\/products\/nifedipine-treat-heart-diseases-high-blood-pressure","provider":"ELIVERA UK","version":"1.0","type":"link"}